After you manage to get rid of him with the Super Drencher, there's a chance he may appear alongside his minions in a random attack at some point after that. His next main appearance in the game is during Optimum Alfred's stay in the Penthouse when he decides that if you and he join forces you can defeat Alfred. He first asks you to gather 5 mechanical skillpoints and later for you to destroy his antenna which is used for communicating with his companions. After Alfred has been defeated, Xizzle states that he will return and conquer Strangetown one day.
He is the only character who appears on the relationships tab to not have a secret.